Environmental or self-antigens and homotypic interactions cause BCR and Toll-like receptor (TLR) signaling, amplifying the response of CLL cells to other signals in the microenvironment and expanding the activation of anti-apoptotic and proliferation pathways.31,32 Genomic research have identified recurrent mutations in genes regulating tumor mobile-microenvironment interactions, that... https://emilye208emu5.loginblogin.com/profile