You will find a launch of norepinephrine through the descending inhibitory bulbospinal neurons that binds to alpha-two-receptors in the dorsal horn to minimize afferent ache transmission and create analgesia. Hence, medicines like clonidine that concentrate on alpha-2 receptors can affect the transmission of pain. On the list of theories https://kalidasf912xnc4.nico-wiki.com/user